{"id":507,"date":"2015-09-13T17:06:37","date_gmt":"2015-09-13T08:06:37","guid":{"rendered":"http:\/\/hiha.hiroshima-u.ac.jp\/?page_id=507"},"modified":"2020-06-01T11:56:06","modified_gmt":"2020-06-01T02:56:06","slug":"results2015-en","status":"publish","type":"page","link":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/results-en\/results2015-en.html","title":{"rendered":"2015"},"content":{"rendered":"<h3>Original papers<\/h3>\r\n<ul>\r\n\t<li>Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae.<br \/>\r\nMurakami S, Shimamoto T, Nagano H, Tsuruno M, Okuhara H, Hatanaka H, Tojo H, Kodama Y, Funato K.<br \/>\r\nScientific Reports., 17 Nov 2015, doi: 10.1038\/srep16319. [<a href=\"http:\/\/www.nature.com\/articles\/srep16319\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>The conserved Wdr8-hMsd1\/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.<br \/>\r\nHori A, Morand A, Ikebe C, Frith D, Snijders AP, Toda T.<br \/>\r\nBiochemical and Biophysical Research Communications., 10 Nov 2015, doi:\u00a010.1016\/j.bbrc.2015.10.169. [<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X15308664\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar Pollen Allergen-Sensitized Monkeys.<br \/>\r\nFujimura T, Fujinami K, Ishikawa R, Tateno M, Tahara Y, Okumura Y, Ohta H, Miyazaki H, Taniguchi M.<br \/>\r\nInt Arch Allergy Immunol.,\u00a03 Nov 2015, doi:\u00a010.1159\/000441141. [<a href=\"http:\/\/www.karger.com\/Article\/Abstract\/441141\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.<br \/>\r\nIkeda A, Kajiwara K, Iwamoto K, Makino A, Kobayashi T, Mizuta K, Funato K.<br \/>\r\nYeast., 2 Nov 2015, doi: 10.1002\/yea.3138. [<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/yea.3138\/abstract;jsessionid=AD9F18591D9C15E9CB755B6668A616D7.f04t03\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Casein kinase 1\u03b3 acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.<br \/>\r\nKoyano T, Barnouin K, Snijders AP, Kume K, Hirata D, Toda T.<br \/>\r\nGenes to Cells., 2 Nov 2015, doi:\u00a010.1111\/gtc.12309. [<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gtc.12309\/abstract\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres.<br \/>\r\nNanbu T, Nguy?n LC, Habib AG, Hirata N, Ukimori S, Tanaka D, Masuda K, Takahashi K, Yukawa M, Tsuchiya E, Ueno M.<br \/>\r\nPLoS One., 14 Oct 2015, doi:\u00a010.1371\/journal.pone.0140456. [<a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0140456\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>The yeast chromatin remodeler Rsc1-RSC complex is required for transcriptional activation of autophagy-related genes and inhibition of the TORC1 pathway in response to nitrogen starvation.<br \/>\r\nYu F, Imamura Y, Ueno M, Suzuki SW, Ohsumi Y, Yukawa M, Tsuchiya E.<br \/>\r\nBiochem Biophys Res Commun., 4 Sep 2015, doi: 10.1016\/j.bbrc.2015.07.114.\u00a0[<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X15303442\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Inhibition of the Arg\/N-end rule pathway-mediated proteolysis by dipeptide-mimetic molecules.<br \/>\r\nKitamura K.<br \/>\r\nAmino acids, 3 Sep 2015, doi:10.\u200b1007\/\u200bs00726-015-2083-1.\u00a0[<a href=\"http:\/\/link.springer.com\/article\/10.1007%2Fs00726-015-2083-1\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.<br \/>\r\nJu KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, van der Donk WA, Metcalf WW.<br \/>\r\nProc Natl Acad Sci U S A., 31 Aug 2015, doi: 10.1073\/pnas.1500873112.\u00a0[<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26324907\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Sphingolipids regulate telomere clustering by affecting transcriptional levels of genes involved in telomere homeostasis.<br \/>\r\nIkeda A, Muneoka T, Murakami S, Hirota A, Yabuki Y, Karashima T, Nakazono K, Tsuruno M, Pichler H, Shirahige K, Kodama Y, Shimamoto T, Mizuta K, Funato K.<br \/>\r\nJ Cell Sci., 15 Jul 2015, doi: 10.1242\/jcs.164160.\u00a0[<a href=\"http:\/\/jcs.biologists.org\/content\/128\/14\/2454.long\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis\u00a0 on allergen-specific immunotherapy.<br \/>\r\nFujimura T and Kawamoto S.<br \/>\r\nAllergology Int., <span class=\"slug-metadata-note ahead-of-print\">Published 3 <span class=\"slug-ahead-of-print-date\">July 2015,<\/span><\/span> doi:<span class=\"slug-doi\" title=\"10.1083\/jcb.201412111\">10.1016\/j.alit.2015.05.008<\/span>. [<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1323893015001197\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts.<br \/>\r\nWan K, Kawara H, Yamamoto T, Kume K, Yabuki Y, Goshima T, Kitamura K, Ueno M, Kanai M, Hirata D, Funato K, Mizuta K.<br \/>\r\nYeast, 29 Jun 2015, doi: 10.1002\/yea.3083. [<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/yea.3083\/abstract;jsessionid=B6996F504C39E388FCB78EFB626C7496.f01t02\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae.<br \/>\r\nImamura Y, Yu F, Nakamura M, Chihara Y, Okane K, Sato M, Kanai M, Hamada R, Ueno M, Yukawa M, Tsuchiya E.<br \/>\r\nPLoS One, 18 Jun 2015, doi: 10.1371\/journal.pone.0130397.\u00a0[<a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0130397\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>\u00a0Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in S. pombe.<br \/>\r\nHabib AG, Masuda K, Yukawa M, Tsuchiya E, and Ueno M.<br \/>\r\nBiochem Biophys Res Commun., <span class=\"slug-metadata-note ahead-of-print\">Published 18 <span class=\"slug-ahead-of-print-date\">Jun 2015,<\/span><\/span> doi:10.1016\/j.bbrc.2015.06.098. [<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X15301509\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>The Msd1\u2013Wdr8\u2013Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.<br \/>\r\nYukawa M, Ikebe C and Toda T.<br \/>\r\nJ Cell Biol, <span class=\"slug-metadata-note ahead-of-print\">Published 18 <span class=\"slug-ahead-of-print-date\">May 2015,<\/span><\/span> doi: <span class=\"slug-doi\" title=\"10.1083\/jcb.201412111\">10.1083\/jcb.201412111<\/span>. [<a href=\"http:\/\/jcb.rupress.org\/content\/early\/2015\/05\/12\/jcb.201412111.abstract\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>] <a href=\"http:\/\/jcb.rupress.org\/content\/early\/2015\/05\/12\/jcb.201412111.full.pdf+html\" target=\"_blank\" rel=\"noopener\">[<span style=\"color: #0000ff;\">pdf<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>A novel anti-histone H1 monoclonal antibody, SSV monoclonal antibody, improves lung injury and survival in a mouse model of lipopolysaccharide -induced sepsis-like syndrome.<br \/>\r\nKusano T, Chiang KC, Inomata M, Shimada Y, Ohmori N, Goto T, Sato S, Goto S, Nakano T, Kawamoto S, Takaoka Y, Shiraishi N, Noguchi T and Kitano S.<br \/>\r\nBiomed Res Int. 2015;2015:491649. doi: 10.1155\/2015\/491649. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25649890\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Centriolar satellites- and hMsd1\/SSX2IP-dependent microtubule anchoring is critical for centriole assembly.<br \/>\r\nHori A, Peddie CJ, Collinson LM, and Toda T.\r\n\r\n<p>Mol. Biol. Cell, 1 Apl 2015 (online), doi:10.1091\/mbc.E14-11-1561. [<a href=\"http:\/\/www.molbiolcell.org\/content\/early\/2015\/03\/30\/mbc.E14-11-1561.abstract\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>] [<a href=\"http:\/\/www.molbiolcell.org\/content\/early\/2015\/03\/30\/mbc.E14-11-1561.full.pdf+html\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">pdf<\/span><\/a>]<\/p>\r\n<\/li>\r\n\t<li>Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity.<br \/>\r\nTamura H, Okada H, Kume K, Koyano T, Goshima T, Nakamura R, Akao T, Shimoi H, Mizunuma M, Ohya Y, Hirata D.<br \/>\r\nBiosci Biotechnol Biochem., 19 Mar 2015 (online), doi:10.1080\/09168451.2015.1020756. [<a href=\"http:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2015.1020756?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%3dpubmed#.VaySWfntif4\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Casein kinase 1\u03b3 ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast. <br \/>\r\nKoyano T, Konishi M, Martin SG, Ohya Y, Hirata D, Toda T, and Kume K.<br \/>\r\nMol Cell Biol., 17 Feb 2015 (online) , doi:10.1128\/MCB.01465-14. [<a href=\"http:\/\/mcb.asm.org\/content\/early\/2015\/02\/11\/MCB.01465-14.abstract\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">abstract<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Alp7\/TACC recruits kinesis-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement. <br \/>\r\nTang NH and Toda T.<br \/>\r\nJ Cell Sci., 2015 Jan 15, 128(2):354-63. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25472718\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">PubMed<\/span><\/a>]<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. <br \/>\r\nKume K, Koyano T, Takara J, Wakabayashi K, Mizunuma M, Miyakawa T, and Hirata D.<br \/>\r\nBiosci Biotechnol Biochem., 2015 Jan 23:1-5. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25614218\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>]<\/li>\r\n\t<li>Isolation and biosynthesis of an azoxyalkene compound produced by a multiple gene disruptant of <em>Streptomyces<\/em> <em>rochei<\/em>. \u00a0Hirofumi Kunitake, Takahiro Hiramatsu, Haruyasu Kinashi, Kenji Arakawa.\u00a0<strong>ChemBioChem<\/strong>,<em>16<\/em> [15], 2237-2243 (2015). DOI: 10.1002\/cbic.201500393<\/li>\r\n\t<li>\u00a0<\/li>\r\n\t<li>The <em>tap<\/em>-<em>tpg<\/em> gene pair on the linear plasmid functions to maintain a linear topology of the chromosome in <em>Streptomyces<\/em> <em>roche<\/em>. \u00a0Yosi Nindita, Zhisheng Cao, Yingjie Yang, <u>Kenji Arakawa<\/u>, Yuh Shiwa, Hirofumi Yoshikawa, Michihira Tagami, Alexander Lezhava, Haruyasu Kinashi.\u00a0<strong>Mol. Microbiol.<\/strong>, <em>95<\/em> [5], 846-858 (2015). DOI: 10.1111\/mmi.12904<\/li>\r\n<\/ul>\r\n<h3>Review<\/h3>\r\n<ul>\r\n\t<li>Centriolar satellite- and hMsd1\/SSX2IP-dependent microtubule anchoring is critical for centriole assembly. <br \/>\r\nAkiko Nishi-Hori, Takashi Toda.<br \/>\r\nExperimental Medicine (Current Topics)., 2015 Nov, Vol.33 No.18, 2994-2997<\/li>\r\n<\/ul>\r\n<ul>\r\n\t<li>MAPping the Ndc80 loop in cancer: A possible link between Ndc80\/Hec1 overproduction and cancer formation. <br \/>\r\nTang NH, Toda T.<br \/>\r\nBioessays., 2015 Jan 2., doi: 10.1002\/bies.201400175. [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25557589\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #0000ff;\">PubMed<\/span><\/a>]<\/li>\r\n<\/ul>","protected":false},"excerpt":{"rendered":"Original papers Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae. Murakami S, Shimamoto T, Nagano H, Tsuruno M, Okuhara H, Hatanaka H, Tojo H, Kodama Y, Funato K. Scientific Reports., 17 Nov 2015, doi: 10.1038\/srep16319. [abstract] The conserved Wdr8-hMsd1\/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. Hori A, Morand A, Ikebe C, Frith D, Snijders AP, Toda T. Biochemical and Biophysical Research Communications., 10 Nov 2015, doi:\u00a010.1016\/j.bbrc.2015.10.169. [abstract] Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":502,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/507"}],"collection":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=507"}],"version-history":[{"count":0,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/507\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/502"}],"wp:attachment":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}