{"id":2878,"date":"2019-01-08T13:54:37","date_gmt":"2019-01-08T04:54:37","guid":{"rendered":"http:\/\/hiha.hiroshima-u.ac.jp\/?page_id=2878"},"modified":"2021-02-13T17:02:40","modified_gmt":"2021-02-13T08:02:40","slug":"2019-2","status":"publish","type":"page","link":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/results-en\/2019-2.html","title":{"rendered":"2019"},"content":{"rendered":"<ul>\r\n\t<li>Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-\u03baB, and STAT3. \u3000Abd El-Hafeez A. A., Khalifa H. O., Mahdy E. A. M., Sharma V., Hosoi T., Ghosh P., Ozawa K., Montano M. M., Fujimura T., Ibrahim A. R. N., Abdelhamid M. A. A., Pack S. P., Shouman S. A.,\u00a0Kawamoto S. (2019) Pharmacol. Rep., doi: 10.1016\/j.pharep.2019.01.001.[<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S173411401830269X\" target=\"_blank\" rel=\"noopener\">abstract<\/a>]<\/li>\r\n\t<li>Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7\/Kinesin-5 motor for mitotic spindle assembly in\u00a0<i>Schizosaccharomyces pombe\u3000\u3000<\/i><i><\/i>Masashi Yukawa, Yusuke Yamada\u00a0and Takashi Toda<br \/>\r\n<div class=\"x_highwire-cite-metadata\"><span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-date\">January 1, 2019\u00a0<\/span><span class=\"x_highwire-cite-metadata-volume x_highwire-cite-metadata\">vol. 9\u00a0<\/span><span class=\"x_highwire-cite-metadata-issue x_highwire-cite-metadata\">no. 1\u00a0<\/span><span class=\"x_highwire-cite-metadata-pages x_highwire-cite-metadata\">269-280;\u00a0<\/span><span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-doi\"><a title=\"\u5143\u306e URL: https:\/\/doi.org\/10.1534\/g3.118.200896 \u3053\u306e\u30ea\u30f3\u30af\u304c\u4fe1\u983c\u3067\u304d\u308b\u5834\u5408\u306f\u30af\u30ea\u30c3\u30af\u307e\u305f\u306f\u30bf\u30c3\u30d7\u3057\u3066\u304f\u3060\u3055\u3044\u3002\" href=\"https:\/\/apac01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fdoi.org%2F10.1534%2Fg3.118.200896&amp;data=02%7C01%7C%7Cab2096460232473ffad408d676ca0862%7Cc40454ddb2634926868d8e12640d3750%7C1%7C0%7C636827007421703991&amp;sdata=oF2n69Kmn3%2FkWB2EuOVlmf2VRmxNrW2udUu1bfTUtvc%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\">https:\/\/doi.org\/10.1534\/g3.118.200896<\/a><\/span><\/div>\r\n<p>\u3010<a href=\"http:\/\/www.g3journal.org\/content\/early\/2018\/11\/21\/g3.118.200896\" target=\"_blank\" rel=\"noopener\">G3<\/a>\u3011\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30463883\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\u3011<\/p>\r\n<\/li>\r\n\t<li>\r\n<p><span style=\"font-size: 1rem;\">Reliable imaging of ATP in living budding and fission yeast<\/span><\/p>\r\n<p><span lang=\"en-US\">Masak Takaine, Masaru Ueno, Kenji Kitamura, Hiromi Imamura, Satoshi Yoshida<\/span><\/p>\r\n<p><span lang=\"en-US\">J Cell Sci 2019 : jcs.230649 doi: 10.1242\/jcs.230649 Published 11 March 2019\u3010<a href=\"http:\/\/jcs.biologists.org\/content\/early\/2019\/03\/06\/jcs.230649\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/span><\/p>\r\n<\/li>\r\n\t<li>\r\n<p><span lang=\"en-US\">Spindle pole body movement is affected by glucose and ammonium chloride in fission yeast<\/span><\/p>\r\n<p><span lang=\"en-US\">Biochemical and Biophysical Research Communications<\/span><\/p>\r\n<p><span lang=\"en-US\">Available online 4 March 2019 In Press,\u3010<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X19303298\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/span><\/p>\r\n<\/li>\r\n\t<li><span style=\"font-family: \u30e1\u30a4\u30ea\u30aa;\">Novel metabolic disturbances in marginal vitamin B6-deficient rat heart.<\/span><br \/>\r\nKumrungsee T, Nirmagustina DE, Arima T, Onishi K, Sato K, Kato N, Yanaka N.<br \/>\r\nJ. Nutr. Biochem. 2019\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30599394\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage.<br \/>\r\nOkazaki Y, Nakamura K, Takeda S, Yoshizawa I, Yoshida F, Ohshima N, Izumi T, Klein JD, Kumrungsee T, Sands JM, Yanaka N.<br \/>\r\nAm. J. Physiol. Cell Physiol. 2019\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30462540\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>Tang, N.H., Fong, C.S., Masuda, H., Jourdain, I., Yukawa, M., and Toda, T. (2019). Generation of temperature sensitive mutations with error-prone PCR in a gene encoding a component of the spindle pole body in fission yeast. Biosci Biotechnol Biochem, 1-4.\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31042107)\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011]<\/li>\r\n\t<li>Generation of temperature sensitive mutations with error-prone PCR in a gene encoding a component of the spindle pole body in fission yeast. Biosci Biotechnol Biochem, 1-4.Tang, N.H., Fong, C.S., Masuda, H., Jourdain, I., Yukawa, M., and Toda, T. (2019). \u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31042107)\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Masashi Yukawa, Masaki Okazaki, Yasuhiro Teratani, Ken\u2019ya Furuta, and Takashi Toda<br \/>\r\n\u63b2\u8f09\u8a8c\uff1aScientific Reports\u3010<a href=\"https:\/\/doi.org\/10.1038\/s41598-019-43774-7\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>\r\n<p>Nuclear membrane protein Lem2 regulates nuclear size through membrane flow.\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Kume K\u00a0,Cantwell H\u00a0Burrell A,\u00a0Nurse P\u3010<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31015410\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/p>\r\n<\/li>\r\n\t<li>\"3-Ketoacyl-ACP synthase (KAS) III homologuyes and their roles in\u00a0natural product biosynthesis\", MedChemComm, 2019.\u00a0Risa Nofiani, Benjamin Philmus, Yosi Nindita, and Taifo Mahmud\u3010<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/MD\/C9MD00162J#!divAbstract\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>Kinesin-8 and TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation.\u3000Corinne L. Pinder, Yuzy Matsuo, Sebastian P. Maurer\u00a0and Takashi\u00a0Toda\u00a0 \u00a0Journal\uff1a<span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-journal-title\">Journal of Cell Science\u00a0\u00a0<\/span><span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-date\">2019\u00a0\u00a0<\/span><span class=\"x_highwire-cite-metadata-volume x_highwire-cite-metadata\">:\u00a0<\/span><span class=\"x_highwire-cite-metadata-pages x_highwire-cite-metadata\">jcs.232306\u00a0<\/span><span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-doi\">doi:\u00a010.1242\/jcs.232306<\/span><span class=\"x_highwire-cite-metadata x_highwire-cite-metadata-doi\">\u3010<a href=\"https:\/\/jcs.biologists.org\/content\/early\/2019\/08\/17\/jcs.232306\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/span><\/li>\r\n\t<li>Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy<br \/>\r\nFront. Immunol., doi: 10.3389\/fimmu.2019.01933\u3000\u3000Takashi Fujimura, Shelly Zing Chin Lum, Yuka Nagata, Seiji Kawamoto and Michiko K. Oyoshi\u3010<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2019.01933\/full\" target=\"_blank\" rel=\"noopener\">full text<\/a>\u3011<\/li>\r\n\t<li>Two XMAP215\/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast.\u3000\u3000Masashi Yukawa, Tomoki Kawakami, Corinne Pinder and Takashi\u00a0Toda\/International Journal of Molecular Sciences 2019 :\u00a020(20), 5108\u3010<a href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5108\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li>Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and\u00a0multipolar mitosis in MDA-MB-231 human cells.\u00a0\u00a0Naoaki Kurisawa,\u00a0Masashi Yukawa,\u00a0Hiroyuki Koshino, Takumu Onodera, Takashi Toda and\u00a0Ken-ichi Kimura\/Bioorganic &amp;\u00a0Medicinal Chemistry\u3010<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968089619310247?via%3Dihub\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u3011<\/li>\r\n\t<li><span style=\"display: inline !important; float: none; background-color: #ffffff; color: #444444; cursor: text; font-family: 'Open Sans',Helvetica,Arial,sans-serif; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;\">The genome sequence of <\/span><em>Streptomyces<\/em> <em>rochei<\/em><span style=\"display: inline !important; float: none; background-color: #ffffff; color: #444444; cursor: text; font-family: 'Open Sans',Helvetica,Arial,sans-serif; font-size: 14px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;\"> 7434AN4, which carries a linear chromosome and three characteristic linear plasmids<\/span>.\u00a0 Yosi Nindita, Zhisheng Cao, Amirudin Akhmad Fauzi, Aiko Teshima, Yuya Misaki, Rukman Muslimin, Yingjie Yang, Yuh Shiwa, Hirofumi Yoshikawa, Michihira Tagami, Alexander Lezhava, Jun Ishikawa, Makoto Kuroda, Tsuyoshi Sekizuka, Kuninobu Inada, Haruyasu Kinashi, Kenji Arakawa. <strong>Scientific Reports<\/strong>, <em>9<\/em>, 10973 (2019). <a href=\"https:\/\/www.nature.com\/articles\/s41598-019-47406-y\">DOI: 10.1038\/s41598-019-47406-y<\/a><\/li>\r\n\t<li>Computational prediction of the mode of binding of antitumor lankacidin C to tubulin. \u00a0Ahmed Taha Ayoub, Mohamed Ali Elrefaiy, Kenji Arakawa.\u00a0<strong>ACS Omega<\/strong>, <em>4<\/em> [2], 4461-4471 (2019). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6648929\/\">DOI: 10.1021\/acsomega.8b03470<\/a><\/li>\r\n<\/ul>","protected":false},"excerpt":{"rendered":"Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-\u03baB, and STAT3. \u3000Abd El-Hafeez A. A., Khalifa H. O., Mahdy E. A. M., Sharma V., Hosoi T., Ghosh P., Ozawa K., Montano M. M., Fujimura T., Ibrahim A. R. N., Abdelhamid M. A. A., Pack S. P., Shouman S. A.,\u00a0Kawamoto S. (2019) Pharmacol. Rep., doi: 10.1016\/j.pharep.2019.01.001.[abstract] Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7\/Kinesin-5 motor for mitotic spindle assembly in\u00a0Schizosaccharomyces pombe\u3000\u3000Masashi Yukawa, Yusuke Yamada\u00a0and Takashi Toda January 1, 2019\u00a0vol. 9\u00a0no. 1\u00a0269-280;\u00a0https:\/\/doi.org\/10.1534\/g3.118.200896 \u3010G3\u3011\u3010PubMed\u3011 Reliable imaging of ATP in living budding and fission yeast Masak Takaine, Masaru Ueno, Kenji Kitamura, [&hellip;]","protected":false},"author":5,"featured_media":0,"parent":502,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/2878"}],"collection":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=2878"}],"version-history":[{"count":0,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/2878\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/pages\/502"}],"wp:attachment":[{"href":"https:\/\/hiha.hiroshima-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=2878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}